Essay --

acetaminophen (Tylenol) is an analgesic medication. Its overdose occurs when aroundone accidently or intentionally takes more than the normal or recommended amount of this medication. Acetaminophen overdose is one of the common poisonings worldwide. If this poisoning occurs, need to call local anaesthetic emergency number (911) or poison control center.Acute acetaminophen overdose is defined as an phthisis of toxic amount of acetaminophen occurring within a stoppage of eighter from Decatur hours or less. In adults acetaminophen toxicity occurs following ingestion of greater than 7.5-10gms over a period of eight hours or less. Chronic acetaminophen overdose occurs following ingestion of toxic amount over a period greater than eight hours. The mechanism of liver injury is related to the fact that small amounts of acetaminophen are converted to a toxic metabolite. The toxic metabolite binds with liver proteins to motive cellular injury. The amount of toxic metabolite produced and the ability of the liver to remove this metabolite let on front it binds to liver protein influence the extent of liver injury. PathophysiologyOral acetaminophen is speedily absorbed from the stomach and small intestines. The serum drug c at a timentration peaks 1-2 hours once after ingestion. Peak plasma level occurs within 4 hours of bet on ingestion of over dose of an immediate release preparation. Therapeutic levels are 5-20 g/ml. Acetaminophen primarily metabolized by liver to non toxic, water soluble form that is eliminated in the urine. Overdose leads to formation of hepatotoxic reactive metabolite causes an ensuring cascade of oxidative damage and mitochondrial dysfunction. This subsequent inflammatory response propagates hepatocellular injury and death. standardised enzymatic reaction occurs i... ...dressed some recommendations to acetaminophen based medications, are serious daily dose for healthy individuals, patients with chronic renal failure, patients who concur rently salute alcohol and appropriate dose needed to be efficacy. It also compel package size restrictions.PreventionPeople supposed to take some steps to avoid acetaminophen overdose. Always securely close the acetaminophen containers and use child proof bottles. Keep all the medication out of the reach of children. Know the correct dose and amount of drug onward administration. Never mix the both medications if those contain the acetaminophen. Keep all the medications international from the family member who are being showed suicidal ideations and seek medical anxiety immediately. Patient should not be taken acetaminophen if he has consumed three alcoholic beverages per day as it leads to hepatotoxicity.